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What Is Hyaluronic Acid Exactly? Hyaluronic acid naturally occurs in our skin. It has an incredible capacity to attract and hold up to 1,000 times its weight in water. When used in topical skincare products, hyaluronic acid acts as a humectant, trapping water against our skin's surface. When used as an injectible, it binds water from surrounding tissues to plump our skin which smooths wrinkles and restores volume. Benefits of Hyaluronic Acid in Topical Skincare Imagine the skin cells of your youth replicating deep in your skin like plump, healthy grapes that hold their moisture throughout their journey to your skin's surface. When they reach the surface, your skin holds that hydration and remains soft, supple, and glowing. As we age, those grapes lose that water on their journey and reach your skin's surface looking more like raisins. However, applying topical hyaluronic acid serums can replace that lost water, reinforce your skin's barrier, and make your skin more resilient and youthful looking. Although using hyaluronic acid for anti-aging concerns is effective, the benefits of this acid extend far beyond just making skin appear more youthful. For one, hyaluronic acid is exceedingly gentle which makes it an excellent moisturizing option for sensitive skin. Because hyaluronic acid is oil-free, it provides hydration for balancing oily skin that may be flaky and dehydrated. Whether used alone or under your favorite cream-based moisturizer or sunscreen, hyaluronic acid can benefit all skin types and concerns. How Does Hyaluronic Acid Work Differently in Injectables? Our skin loses collagen, elastin, hyaluronic acid, fat, and even bone as we age. The degradation of these vital skin structures res

Visible aging signs appear as people become older as a result of the action of the sun, vicious habits, and lifestyle. The earliest aging signs include thinning of the skin, loss of the fullness of facial contours, and appearance of wrinkles. The exciting news is that over the past ten years there has been an impressive array of new approved products that have become available that not only fill lines and wrinkles, but actually help re-contour, rejuvenate, volumize and restore the face, and even other areas of the body such as the hands, to a natural more youthful appearance without going under the knife. The new products do not require skin testing, have much greater longevity, and are very safe when performed by properly trained dermatologists. What is hyaluronic acid? Hyaluronic acid is a substance that is naturally present in the human body. It is found in the highest concentrations in fluids in the eyes and joints. The hyaluronic acid that is used as medicine is extracted from rooster combs or made by bacteria in the laboratory. Hyaluronic acid is a major component of skin, where it is involved in tissue repair. Is the procedures painful? Many treatments do not require anesthetics. However, some patient feels more comfortable with an anesthetic cream. Is this procedure safe? Hyaluronic acid is safe when injected appropriately. Rarely, hyaluronic acid may cause allergic reactions. Side effects are temporary and should only last a few days. They may include: Bleeding from the injection sites Swelling and bruising Redness and tenderness at the site of the injection

If you really want to up your skincare game, the best way to do so is by learning exactly what`s in the products you`re putting on your face. Sounds like common sense, but you wouldn`t believe how many people never even bother to read the ingredients lists. They`re more interested in the promises a product makes, like [erases wrinkles" or [bye-bye age spots!" Here`s the thing: there are a LOT of skincare products in the world, and they all need a way to get you to fork over your cash. It makes a lot more sense to get educated about what products are really worth paying the money for. And in the case of hyaluronic acid, one of the power players, you won`t need to pay much at all if you play your cards right What is Hyaluronic Acid Hyaluronic acid (HA) is a molecule that naturally occurs in the human body. It helps make up the connective tissues in your body and keeps hair, skin, joints, nerves, and eyes well lubricated. It holds a thousand times its weight in water, which is why it`s such a power player in keeping our skin moist and glowy. But as we grow older, our bodies naturally produce less HA. That means skin will naturally become drier and less bouncy as we age unless we replenish what`s lost in our skincare routine. When people go to med spas for procedures guess what they`re getting injected? A gel form of hyaluronic acid. How do I choose the right hyaluronic acid product? Before you go grabbing every HA product off the shelves, there are a few other tidbits to be aware of. One, HA works well alongside most other star skincare ingredients (think actives like AHAs and BHAs), so there are no worries about how it will play with the rest of your routine. Another thing to keep in mind about HA is that it does its best work at what

What is hyaluronic acid Hyaluronic Acid is powerful stuff. But don`t let the word [acid" fool you. This gel-like water-holding molecule is a moisture-binding ingredient that helps keep skin plump and hydrated. And, it`s actually something our bodies naturally produce. Hyaluronic Acid helps retain over 1,000 times its weight in water within the cells of skin, making it an excellent moisturizer. Scientific studies have shown that Hyaluronic Acid helps improve skin hydration and production of collagen, fight free radicals, maintain skin elasticity, and even has antibacterial and anti-inflammatory properties that help with wound healing. Yes, please! So why do we need more if our bodies already produce it? Well, the average human body contains about 15 grams of Hyaluronic Acid. However, one third of that gets degraded and synthesized on a daily basis. We also produce less and less as we age. So we want more, which is why many anti-aging products contain Hyaluronic Acid. Plastic surgeons often inject Hyaluronic Acid into sunken areas of skin t

Hyaluronic acid is a substance that occurs naturally in the skin, eyes, and joints. Its primary function is to trap water inside tissue cells, keeping the eyes moist and the joints lubricated. Hyaluronic acid also has many medical and commercial uses. It is available in a variety of forms, including: dietary supplements.face creams.serums.eye drops.injections Uses and benefits Some people use hyaluronic acid to promote skin health and fight signs of aging. It may help wounds heal, too. Some doctors also use hyaluronic acid to relieve joint pain in people with arthritis. The skin contains about halfTrusted Source of the hyaluronic acid in the body. Hyaluronic acid binds to water molecules, which helps keep the skin hydrated and supple. Levels of hyaluronic acid in the skin significantly decrease as people age, which can lead to dehydrated skin and wrinkles. Taking hyaluronic acid or using cosmetic products that contain it may improve skin hydration and reduce signs of aging Is it effective? Researchers have looked at whether hyaluronic acid is effective for a range of uses: Anti-aging The anti-aging effects of hyaluronic acid products may vary from person to person, depending on other factors that influence the skin, such as: genetics.nutrition.smoking and alcohol consumption.pollution.sun exposur.Relieving joint pain Synovial fluid lubricates and cushions the joints. This fluid contains hyaluronic acid. Over time, the hyaluronic acid in synovial fluid breaks down, which contributes to joint pain and stiffness, according to the Arthritis Foundation. Doctors can use hyaluronic acid injection

An Irreplaceable natural substance in the human body "Hyaluronic acid, which is hyaluronic acid, is actually a natural component in the human body. It is a natural linear polysaccharide present in human and animal tissues. It is mainly distributed in the vitreous, joint, umbilical cord, skin and other parts of the human body. To play important physiological functions. Hyaluronic acid is an irreplaceable natural substance in the human body. It is high in the body during embryonic period, and its body content decreases with age. If the relative content of hyaluronic acid in the human body at the age of 20 is 100%, it will decrease to 65%, 45%, 25% at 30, 50, and 60 years old, skin aging, joint deterioration, arteriosclerosis, and old eyes. The symptoms are closely related to the gradual decrease in hyaluronic acid content in the body. The amount of hyaluronic acid contained in the same age group is also different, and the content of the body of the premature aging is significantly reduced, showing many symptoms of aging. Hyaluronic acid was first discovered in 1934 by Meyer, a professor of ophthalmology at Columbia University in the United States, who first isolated hyaluronic acid from the vitreous vitreous and analyzed its structure. In addition to the bull's eye, the highest content of hyaluronic acid in nature is the cockscomb and the human baby's umbilical cord. In the 1970s, people began to extract hyaluronic acid from the cockscomb. However, the hyaluronic acid extracted from animal tissues has a good effect, but the extraction rate is extremely low, the separation process is complicated, and the yield is limited, which also makes the hyaluronic acid expensive. , up to $5,000 / kg. In the 1990s, the domestic research on the fermentation technology of hyaluronic aci

Product Introduction: Chondroitin Sulfate is a chemical that is normally found in cartilage around joints in the body. Chondroitin sulfate is manufactured from animal sources, such as cow cartilage.Chondroitin sulfate is an important structural component of cartilage and provides much of its resistance to compression. Along with glucosamine, chondroitin sulfate has become a widely used dietary supplement for treatment of osteoarthritis. It is now widely used in nutraceutical , pharmaceutical, food, and cosmetics industries.

From experiments, researchers compare the efficacy of delivering hyaluronic acid gel injections to the upper lip through needle or micro-cannula injections. The most desirable results are correlated with the infiltration of hyaluronic acid to the muscle layers of the lip. One of the hallmarks of the aging face is the loss of upper lip volume. Our skin loses its moisture and elasticity, and this is even more obvious in the moisture-rich mucous regions of the lips. Coupled with the shrinking of the surrounding fat and soft tissue, the result is a decrease in the volume of the upper lip, and the wrinkles on the skin surrounding the lips only further accentuates this volume loss. Aside from these age-related changes, current standards of beauty also place an emphasis on fuller, robust lips; these reasons have contributed to the ever-increasing popularity enhancing the lips through hyaluronic acid gel injections. Hyaluronic acid (HA) gel is most commonly used by clinicians to address these anatomical changes, owing to the predictability of its results and its high safety profile. Achieving the best outcomes also involves understanding lip aesthetics: instead of haphazardly infiltrating the lip with HA and simply `plumping it up`, injecting it in specific areas (the vermillion junction or where the `dry` and `wet` parts of the upper lip meet) creates the most natural result, and thus the best cosmetic profile. Currently, dermatologists and plastic surgeons deliver HA into the upp

Chondroitin sulfate (CS) is a class of glycosaminoglycans covalently linked to proteins to form proteoglycans. Chondroitin sulfate is widely distributed in the extracellular matrix and cell surface of animal tissues. The sugar chain is composed of alternating glucuronic acid and N-acetylgalactosamine (also known as N-acetylgalactosamine) disaccharide units through a sugar-like substance. The linker region is attached to the serine residue of the core protein. At present, the main sources of chondroitin sulfate extraction are sharks, cattle, pigs, and chicken cartilage. In Europe, America, Japan and other countries, chondroitin sulfate is mainly used as a health food or medicine for the prevention and treatment of diseases such as arthritis, coronary heart disease, keratitis and angina pectoris. 1, chondroitin sulfate has a strong role in scavenging oxygen free radicals There are many types of oxygen free radicals that cause oxidative damage in the human body, and the hydroxyl radical superoxide anion radicals have the strongest activity. Studies have shown that chondroitin sulfate hydroxyl radical scavenging activity and superoxide anion free radical activity are relatively high, the half inhibitory concentrations are 8.77mg / mL and 0.94mg / mL, respectively, the scavenging capacity and chon

Hyaluronic acid holds a special place in the upper echelons of skincare ingredients. Unlike many actives, it`s suitable for every skin type and its gentleness doesn`t compromise its effectiveness. One reason behind its universal appeal is its natural prevalence in skin. It can be found in (or between) virtually every cell of your body. Nearly half of this naturally occurring hyaluronic acid is found in your skin, where it plays a role in several vital processes. This can-do molecule aids in tissue repair and wound healing, while also scavenging free radicals to reduce oxidative damage from pollution and UV exposure. On top of all those benefits, it also offers impressive moisture retention capabilities-it can hold up to a thousand times its weight in water. When applied to skincare, these properties make it a fantastic humectant for lasting hydration. With so many benefits, the decision to include hyaluronic acid in several of my products seems like a no-brainer. If forms the cornerstone of my Hydrate Facial Serum and complements the formula of my Hydrate Mist. The mist features a high molecular weight hyaluronic acid (often abbreviated as HMW HA). Due to its larger size, this hyaluronic acid form sits closer to the surface of the skin where it`s better able to prevent moisture loss. HMW excels at keeping skin hydrated and elastic. By contrast, low molecular weight hyaluronic acid (or LMW HA) has been bioengineered into smaller pieces. The compound is identical to HMW HA, just reduced in size. These tiny molecules penetrate deeper in the epidermal layers, giving LMW HA a kind of plumping effect that leaves skin looking full, bouncy, and youthful. LMW and HMW hyaluronic acids work exceptionally well in tandem. That way, you gain the benefits of both! .Like hyaluronic aci

What is hyaluronic acid? "Hyaluronic acid is a naturally-occurring sugar molecule,It can be used in both skincare ingredients and in injectables, but it's also found in the body as one of the agents that helps to make collagen. So the collagen in your skin and joints is composed partly of hyaluronic acid, plus protein." What do we use hyaluronic acid for? "Its main use in skin creams is as a humectant - which is one of the agents that's able to hold moisture on the skin's surface,It can actually hold up to 1000 times its weight in moisture! So it's a really good hydrator of the skin." "The other main use is as a volumising and line-filling injectable,We connect multiple hyaluronic acid molecules together to give a more robust substance, which is then injected under deeper scars, wrinkles and fine lines - it comes in different thicknesses. Because it's injected, it penetrates much further and produces collagen, to more effectively plump and reduce lines." What else do we need to know? "Applied topically on the skin, hyaluronic acid makes the skin feel smoother and look smoother - but it is only temporary,It's an excellent skin ingredient, as it rarely produces any allergies or irritation." Can anybody use it?

If you really want to up your skincare game, the best way to do so is by learning exactly what`s in the products you`re putting on your face. Sounds like common sense, but you wouldn`t believe how many people never even bother to read the ingredients lists. They`re more interested in the promises a product makes, like [erases wrinkles" or [bye-bye age spots!" Here`s the thing: there are a LOT of skincare products in the world, and they all need a way to get you to fork over your cash. It makes a lot more sense to get educated about what products are really worth paying the money for. And in the case of hyaluronic acid, one of the power players, you won`t need to pay much at all if you play your cards right. What is hyaluronic acid? Hyaluronic acid (HA) is a molecule that naturally occurs in the human body. It helps make up the connective tissues in your body and keeps hair, skin, joints, nerves, and eyes well lubricated. It holds a thousand times its weight in water, which is why it`s such a power player in keeping our skin moist and glowy. But as we grow older, our bodies naturally produce less HA. That means skin will naturally become drier and less bouncy as we age unless we replenish what`s lost in our skincare routine. How do I choose the right hyaluronic acid product? Before you go grabbing every HA product off the shelves, there are a few other tidbits to be aware of. One, HA works well alongside most other star skincare ingredients (think actives like AHAs and BHAs), so there are no worries about how it will play with the

Transparent quality acid originally on exists skin within, can help skin from body and the skin surface sucking have water, also can enhanced skin long time of insurance water capacity. Dang transparent quality acid absorption water Hou, makes stretch fiber and the collagen protein in full wet of environment in the, skin so has has elastic. but, skin of transparent quality acid from 25 age yihou on began loss, 30 age Shi only left infant period 65%, and 60 age Shi only left 25%, skin of water also will followed transparent quality acid and lost, lost elastic and gloss, Wrinkles of aging over time will occur. Moisturizing and barrier is skin care of double mission, real high quality of transparent quality acid must is macromolecules and small molecular transparent quality acid of organic combined, macromolecules transparent quality acid (tens of thousands of to hundreds of thousands of Dalton) cannot penetrating skin, but can in skin surface formed a layer breathable of film, makes skin smooth wet, and can barrier foreign bacteria, and dust, and UV of invaded, protection skin from by against; small molecular transparent quality acid (low to 1000 molecular volume of nano transparent quality acid HA800,OCO small molecular can easily penetrating skin) Has anti-inflammatory, resist bacteria and keep skin smooth; can penetrate the skin, synthetic skin endogenous hyaluronic acid molecules to achieve water conservation function; provide appropriate places for cell proliferation and different

Hyaluronic acid (also known as hyaluron) is a favorite in the cosmetics industry. Many day creams, night creams, facial masks, etc. rely on this tried-and-tested active moisturizing ingredient. It is now also included as an ingredient in nutritional supplements. But is it any different from the hyaluronic acid used in cosmetics? And can our bodies even utilize orally ingested hyaluronic acid? Studies from recent years clarify the issue. Hyaluronic acid is a substance that occurs naturally in the human body. It is mostly found in the skin, connective tissue, joint fluid, vertebral disks and eyeballs. Hyaluronic acid functions as an essential factor in human vitality because it has the special property of binding a lot of water compared to its mass. From a chemical perspective, hyaluronic acid comes in various forms. Different qualities of this care substance are available on the market: Low molecular hyaluronic acid has a longer-term effect and is stored in the connective tissue. Its molecules are smaller and can therefore penetrate into the skin more deeply. The anti-wrinkle effect lasts longer.High molecular hyaluronic acid, in contrast, cannot penetrate as deeply into the skin. The most it can do is form a film of moisture on the outer layer of the skin that releases moisture and improves elasticity. Fine lines and wrinkles appear smoother and plumper. So what happens with hyaluronic acid in nutritional supplements? Both low and high molecular hyaluronic acids are absorbed and dispersed in connective tissue; intestinal bacteria break up the molecules of the high molecular hy

News has recently focused on the possible anti-aging benefits of hyaluronic acid, also known as Hyaluron or HA. In fact, a large pharmaceutical company in Japan began Research & Development on a pill supplement containing HA. When they tested the pills on one thousand individuals, around half of them reported improved eyesight and softer smoother skin. Hyaluronic acid has also proven effective in lubricating arthritic joints. Certain studies have shown positive results from injections of Hyaluronic Acid into the joints that may delay the need for a joint replacement. Hyaluronic acid helps to store water in the skin, providing essential moisture to body processes. Although Hyaluronic Acid is plentiful in our bodies when we are born, the levels of HA slowly decrease over time. This reduction in HA levels may be a big part of the aging process many people are trying to overcome. Hyaluronic Acid occurs in the deeper layers of our skin known as the dermis and it appears to help keep the skin smooth because of its water retention qualities. It also appears to help maintain collagen levels which significantly prolong the aging process. Under normal circumstances, collagen depletion is widely considered to be a prime factor in fine lines and wrinkles as well as elasticity of the skin, both things that are often associated with the visual aging process. There are many different options for supplementing your natural supply of hyaluronic acid. Currently, the most popular choices of hyaluronic acid are supplements and products to combat signs of aging and as therapy for certain joint ailments. There are numerous skin care products that contain Hyaluron acid or have as its ma

Abstract We investigated the functionality of(γ-PGA), which is produced by Bacillus subtilis D7, for its potential applications in medicine and cosmetics. The γ-PGA had angiotensin-converting enzyme (ACE) inhibition activity. ACE inhibition activity was dependent on the γ-PGA concentration; the highest ACE inhibition activity was observed at 1.25 mg/l of γ-PGA. IC50 (0.108 mg/ml) of the γ-PGA was lower than that of standard ACE inhibitory drug, N-[(S)-mercapto-2-methylpropionyl]-L-proline (0.247 mg/ml). The γ-PGA also had water-holding capacity and hygroscopicity. Furthermore, the γ-PGA inhibited growth of some pathogenic bacteria, including Listeria monocytogenes, Salmonella typhimurium, Staphylococcus aureus, Klebsiella pneumonia and Esherichia coli. The γ-PGA exhibited a good metal adsorption capacity; Cr (VI) adsorption capacity of γ-PGA increased with decreasing pH, and the maximal adsorption was observed at pH 2. Our results suggest that γ-PGA may be expected to be widely applied in cosmetics, biomedical and environmental industries with the feature of being less harmful to humans and the environment. 1. Introduction Poly-γ-glutamic acid (γ-PGA) is produced by a number of species of Bacillus. It is an unusual anionic polyamide that is made of d- and l-glutamic acid units connected by amide linkages between α-amino and γ-carboxylic groups. The γ-PGA is biodegradable, edible, water-soluble and non-toxic to humans and environment. Therefore, it has been suggested for use as biodegradable plastics (Tsutomu and Makoto, 2002), flocculants (Bajaj and Singhal, 2011), biological adhesive (Otani et al., 1996) and food additives (Lee and Kuo, 2011). For example, flocculating activity of the γ-PGA pro

Chondroitin sulfate is a glycosaminoglycan, a natural component of cartilage. It is extracted from shark or cow cartilage or manufactured synthetically. Its composition can vary. It is frequently combined with glucosamine. Chondroitin sulfate is used to treat osteoarthritis. Scientific evidence shows no benefit when chondroitin sulfate is taken by itself. However, evidence suggests that in combination with glucosamine, it may reduce joint pain, improve joint mobility, and allow reduction of the doses of conventional anti-inflammatory drugs when it is taken for 6 to 24 mo. Effects over longer periods are unclear. Mechanism is unknown. Dose is 600 mg po once/day to 400 mg po tid. Evidence on efficacy of chondroitin sulfate is conflicting. Until recently, only small trials had studied chondroitin sulfate alone or in combination with glucosamine to treat osteoarthritis. The Glucosamine/Chondroitin Arthritis Intervention Trial (GAIT), a large, randomized, double-blinded, placebo-controlled, multicenter clinical trial studied use of glucosamine (500 mg po tid), chondroitin sulfate (400 mg po tid), and use of both drugs to treat osteoarthritis of the knee; in the group as a whole, pain was not reduced. However, exploratory subanalyses suggested efficacy in a subgroup of patients with moderate-to-severe knee pain A review of 43 randomized, controlled trials has also suggested that the benefit of chondroitin is limited to slight pain improvement in short-term studies, although quality of life may improve . It has been suggested the reason for conflicting symptomatic benefit is due to the poor quality of several food-grade chondroitin sulfate s

What is it? Chondroitin is a dietary supplement and a vital part of cartilage. Studies have found that taking chondroitin can prevent cartilage breaking down and can also stimulate its repair mechanisms. Chondroitin has been tested in at least 22 RCTs for osteoarthritis. Evidence is inconsistent but many show that it has significant clinical benefits in reducing pain and painkiller use. Higher quality trials were less likely to show benefit. Family: Nutritional supplement Scientific name: Chondroitin sulphate Other names:CSA, CDS, CSC Chondroitin is a complex sugar produced from the cartilage of cows, pigs and sharks. You can buy chondroitin capsules from pharmacies and supermarkets. It`s usually sold in combination with glucosamine sulphate. How does it work? Chondroitin is found naturally in your body. It`s a vital part of cartilage, giving it elasticity by helping it retain water. Laboratory studies have found that chondroitin can reduce the activity of enzymes and substances that break down collagen in joints. Other studies have demonstrated that it has several anti-inflammatory properties. Research on animals has found that chondroitin can prevent the breakdown of cartilage and can also stimulate repair mechanisms.

Hyaluronic acid Chemistry and physicochemical properties HA is a non-sulphated GAG and is composed of repeating polymeric disaccharides of D-glucuronic acid and N-acetyl-D-glucosamine linked by a glucuronidic β (1→3) bond. In aqueous solutions HA forms specific stable tertiary structures.Despite the simplicity in its composition, without variations in its sugar composition or without branching points, HA has a variety of physicochemical properties. HA polymers occur in a vast number of configurations and shapes, depending on their size, salt concentration, pH, and associated cations.Unlike other GAG, HA is not covalently attached to a protein core, but it may form aggregates with proteoglycans.HA encompasses a large volume of water giving solutions high viscosity, even at low concentrations.

While we can't imagine ever parting with our hyaluronic acid serums and creams, every now and then, a new, buzzy ingredient will come along to remind us that perhaps HA isn't the be-all and end-all of skin hydrators. Case in point: polyglutamic acid (PGA), a water-soluble peptide that's quickly shaking up the beauty industry. Research on naturally occurring poly-γ-glutamic acid (γ-PGA) - a molecule found in the bacteria of fermented soybeans - suggests it has the ability to hold more moisture than hyaluronic acid. Like four to five times more. "Polyglutamic acid is an excellent humectant, similar to hyaluronic acid," says Dr. Monica Li,"In the lab, polyglutamic acid, as a gel, has been found to be able to absorb moisture up to 5,000 times its own weight," says Dr. Li. "But the actual water amount retained depends on the acidity, or pH, and salt content of the gel." By comparison, hyaluronic acid holds up to 1,000 times its weight in water. However, Dr. Li suggests that the two ingredients need not be seen as competitors. In fact, when used together, they could actually end up being the ultimate recipe for hydrated skin. "Polyglutamic acid may inhibit hyaluronidase, which breaks down hyaluronic acid," explains Dr. Li. PGA also essentially creates a seal that keeps moisture from escaping. It could be quite "complementary to hyaluronic acid, which is found in the deeper skin layers," says Dr. Li. While hyaluronic acid works within the skin to increase mois