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Sodium Chondroitin Sulfate Extracted From Shark Cartilage Top Quality 9007-28-7

Sodium Chondroitin Sulfate Extracted From Shark Cartilage Top Quality 9007-28-7

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Sodium Chondroitin Sulfate Extracted from Shark Cartilage Top Quality 9007-28-7


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Research 


Chondroitin sulfate is used in a wide variety of areas of research such as bioengineering. Chondroitin sulfate may be used as a biomaterial copolymer or surface derivatization reagent in the development of drug delivery vehicles, tissue engineering devices and bioscaffolds. Chondroitin sulfate may be used for the development of biocompatible structures such as hydrogels, sponges, biofilms, microspheres and micelles.

 

Shark cartilage is a dietary supplement made from the dried and powdered cartilage of a shark; that is, from the tough material that composes a shark's skeleton.

 

While shark cartilage does not seem to be an effective treatment for cancer, some studies suggest that intake of one of its key components, chondroitin sulfate, may have positive effects on patients suffering from arthritis.That substance, however, is found in all animal cartilages, and not just that of sharks.


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Glucosamine and Chondroitin Yield


Glucosamine is one of amino glucose compounds extensively found in the cartilage and possesses very important role in health and joint malleability. Its function in the body is to produce synovial fluid working as lubricant of the cartilage that the cartilage moves well. Synovial fluid defficience will cause joint disturbances, such as stuffy joint, and could cause Osteoarthritis (OA) as well. Glucosamine sulphate (2-Amino-2-deoxy-D-glucose sulphate) is salt of glucosamine with chemical structure of C6H13NO5(H2SO4) that is a natural compound in human body consisting of glucose and glumatime amino acid. 


Glucosamine is also main element of GAG (glycosaminoglycan) in the cartilage and synovial fluid. Glucosamine is obtained from skin or shell extraction of crustacean, such as skrimp, lobster, and crab, which through deproteinization and decalciumization, becomes chitin then hydrolized to be glucosamine. It could be found in nearly all body tissues including cartilage. 


Shark whose bones are cartilageous contain mucopolysacharides, including chondroitin and glucosamine.Chondroitin Sulphate (CS) is an unbranched long chained-heteropolysacharide called glycosaminoglycans (GAGs). GAGs is a heteropolysacharide possessing negative edge binding protein called mucopolysacharide. CS is major component of the extracellular matrix which plays a role in maintaining the structural integrity of the tissue. 


Cartilage is an important structural component for defense against pressure. CS is anionic polysacharide consisting of disacharide unit structure, N-Acetylgalactosamine 4- or 6-sulphate and D-glucoronic acid. In the cartilage tissue, the polysacharide is covalently bound to protein to make proteoglycan. CS has extensive application in pharmaceutical, cosmetic, food industries. For instance, CS hasbeen known possessing chondroprotective and anti-arthergenic effects on test animals. 


Technical Standards


Test Items

Specifications

Assay

≥90%

Appearance

Off-White Powder

Optical Rotation

(–12°) ~ (-20°)

Loss on drying

10%

Protein

≤3.0%

Residue on Ignition

20.0%~30.0%

Chlorides

≤0.50%

Sulphates

≤0.24%

PH (1% Solution)

5.5 – 7.5

Heavy Metals

≤20ppm

Arsenic

1ppm

Total plate count

1,000cfu/g

Yeast & Mold

100cfu/g

E. Coli

Negative

Salmonella

Negative



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