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90% Shark Cartilage Food Supplements Chondroitin Sulafate

90% Shark Cartilage Food Supplements Chondroitin Sulafate

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90% Shark Cartilage Food Supplements Chondroitin Sulafate


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Introduction


Chondroitin sulfate is an important and major component of articular cartilage, where it occurs as part of the large proteoglycan, aggrecan. In the early stages of joint disease, both in animal models and in man, there are change in chondroitin sulfate that affect the chain length and the pattern of sulfation. These changes can be detected by monoclonal antibodies and appear to reflect part of the cellular response by the chondrocytes to damage to the articular cartilage matrix. The specificity of the changes show that the biosynthesis of chondroitin sulfate is under tight cellular control in chondrocytes and suggests that selected patterns of sulphation within chains are expressed to suit different biological functions.

 

Chondroitin Sulfate is a molecule, which occurs naturally in the body. It is an important component of cartilage - the tough connective tissue that cushions the joints. The molecule was discovered in the cartilage of cows in 1861 by a German chemist, Fischer.

 

Chondroitin Sulfate is a muco-polysaccaride (glucosaminoglycan) with a high viscosity and the N-acetylgalactosamine as repeated link and with a sulfate group pr. disaccharide unit. The most frequently found muco-polysaccarides in the body are Chondroitin-4-Sulfate and Chondrotin-6-Sulfate. They are present in both bones and connective tissues.


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The Functions of Chondroitin Sulfate


Chondroitin Sulfate has several functions. It delivers nutrients to the joint cartilage, helps to inhibit the enzymes that decompose the joint cartilage and speeds up the formation of a new joint cartilage. As a result, the elasticity and plasticity, which are the functions of the joint cartilage can be maintained through the use of Chondroitin Sulfate.

 

In recent years, research has made great progress, and its various functions including actions on the joint of the knee has become elucidated one after another. As a result, it is now considered an essential substance for the maintenance of healthy joints.

 

Uses of Chondroitin Sulfate


Chondroitin Sulfate is used in many different food and pharmaceutical products. From food supplements, beauty and personal care products, to veterinarian products and pet food.

 

The consensus of expert and industry opinions supports the use of Chondroitin Sulfate and its common partner agent, glucosamine, for improving symptoms, stopping - or possibly reversing - the degenerative process of osteoarthritis.


Technical Standard


Test Items

Specifications

Appearance

White to off-white Powder

Odor

Characteristic

Clarity

Colorless and transparent

Assay

Min. 90%(dry product, HPLC area method)

Specific Rotation

-12°- -19°

Protein

Max. 6.0%

PH (1% solution)

5.5-7.5

Loss on Drying

Max.10%

Residue on Ignition

20.0%-30.0%

chloride

Max.0.50%

Sulfate

Max.0.24%

Heavy metals

Max.20ppm

Total plate count

Max. 10000cfu/g



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