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At room temperature, it is a white powder, odorless, tasteless. It has a strong ability of water absorption. It is highly soluble in water to become a solution with high viscosity. It become unstable upon higher temperatures or acidic condition, primarily being deacetylated or being degraded into monosaccharide or smaller molecular-weight polysaccharide. It is not soluble in organic solvent like ethanol, acetone and ether. Its salt is quite stable to heat without being destroyed when heated to 80 °C.
Chondroitin sulfate is a mixture of acid mucopolysaccharides extracted from the cartilage of pigs, cattle, chicken, and shark cartilage. According to their differences in chemical composition and structure, it is divided into A, B, C, D, E, F, H, etc. It mainly contains mucopolysaccharides such as chondroitin sulfate A and chondroitin sulfate C. Both chondroitin sulfate A and C contain D-glucuronic acid and 2-hydroperoxy group-deoxy-D-galactose, and contain equal amounts of acetyl and sulfuric acid residue. The only difference between them is the different position of sulfuric acid ester on the hexosamine residues. Chondroitin sulfate A can enhance the activity of lipase, causing the decomposition of triglyceride in chylomicron so that the blood will become clean due to the decrease of chylomicrons.
It has anticoagulant and antithrombotic effect, and thus is clinically used for the treatment of coronary artery disease, elevated blood lipids and cholesterol, angina, neuralgia, myocardial ischemia and myocardial infarction embolism.
1. Chondroitin sulfate is mucopolysaccharides-class substance extracted from animal cartilage. It has an important role in prevention and treatment of cardiovascular disease, joint disease, and currently is an important biochemical product on the market.
2. As a health food or drugs, chondroitin sulfate has been long used to prevention and treatment of coronary heart disease, angina, myocardial infarction, coronary atherosclerosis, myocardial and ischemia with no significant side effects. It can significantly reduce the incidence and mortality of coronary heart disease. Long-term clinical application finds that the deposited fat can in the walls of arteries and veins can be effectively reduced or removed, which can significantly lower plasma cholesterol level, and thus preventing the formation of atherosclerosis.
3. Chondroitin sulfate can also be used for the treatment of neuropathic pain, nerve migraine headaches, joint pain, arthritis and scapular joint pain, pain after abdominal operation.
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